IgG Fc glycosylation as an axis of humoral immunity in childhood

J Allergy Clin Immunol. 2020 Feb;145(2):710-713.e9. doi: 10.1016/j.jaci.2019.10.012. Epub 2019 Oct 24.

Abstract

IgG Fc glycans were characterized in 225 healthy children and 40 children with unexplained recurrent respiratory infections, revealing age-dependent variation and suggesting a role for IgG glycosylation in immunocompetence.

Publication types

  • Letter
  • Research Support, N.I.H., Extramural
  • Research Support, N.I.H., Intramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Child
  • Child, Preschool
  • Female
  • Glycosylation
  • Humans
  • Immunity, Humoral / immunology*
  • Immunoglobulin Fc Fragments / chemistry
  • Immunoglobulin Fc Fragments / immunology*
  • Immunoglobulin G / immunology*
  • Infant
  • Male

Substances

  • Immunoglobulin Fc Fragments
  • Immunoglobulin G
  • glycosylated IgG