A Stroke Recovery Trial Development Framework: Consensus-Based Core Recommendations from the Second Stroke Recovery and Rehabilitation Roundtable

Neurorehabil Neural Repair. 2019 Nov;33(11):959-969. doi: 10.1177/1545968319888642. Epub 2019 Nov 1.

Abstract

A major goal of the Stroke Recovery and Rehabilitation Roundtable (SRRR) is to accelerate development of effective treatments to enhance stroke recovery beyond that expected to occur spontaneously or with current approaches. In this paper, we describe key issues for the next generation of stroke recovery treatment trials and present the Stroke Recovery and Rehabilitation Roundtable Trials Development Framework (SRRR-TDF). An exemplar (an upper limb recovery trial) is presented to demonstrate the utility of this framework to guide the GO, NO-GO decision-making process in trial development.

Keywords: GO NO-GO; Stroke; consensus; recovery; rehabilitation; trial design.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Clinical Trials as Topic* / methods
  • Clinical Trials as Topic* / standards
  • Consensus*
  • Guidelines as Topic* / standards
  • Humans
  • Research Design* / standards
  • Stroke / therapy*
  • Stroke Rehabilitation* / methods
  • Stroke Rehabilitation* / standards

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