Surveillance Endoscopy in the Management of Hereditary Diffuse Gastric Cancer Syndrome

Clin Gastroenterol Hepatol. 2021 Jan;19(1):189-191. doi: 10.1016/j.cgh.2019.10.033. Epub 2019 Oct 31.

Abstract

Hereditary diffuse gastric cancer (HDGC) syndrome results from a germline CDH1 mutation, and microscopic foci of signet-ring carcinoma cells (SRCC) are present in nearly all gastrectomy specimens.1 The lifetime risk of invasive gastric cancer (GC) has been thought to be 70%,2 but recent data have suggested a lower risk of 37%.3 Prophylactic total gastrectomy is considered the standard of care, but many patients choose surveillance endoscopy instead. We sought to define the outcomes in CDH1-positive individuals who pursued endoscopic surveillance.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Carcinoma, Signet Ring Cell* / genetics
  • Carcinoma, Signet Ring Cell* / surgery
  • Gastrectomy
  • Gastroscopy
  • Genetic Predisposition to Disease
  • Humans
  • Neoplastic Syndromes, Hereditary* / genetics
  • Stomach Neoplasms* / diagnosis
  • Stomach Neoplasms* / surgery