Abstract
The Nr4a family of nuclear hormone receptors is composed of three members-Nr4a1/Nur77, Nr4a2/Nurr1 and Nr4a3/Nor1. While currently defined as ligandless, these transcription factors have been shown to regulate varied processes across a host of tissues. Of particular interest, the Nr4a family impinge, in a tissue dependent fashion, on cellular proliferation, apoptosis and fuel utilization. The regulation of these processes occurs through both nuclear and non-genomic pathways. The purpose of this review is to provide a balanced perspective of the tissue specific and Nr4a family member specific, effects on cellular proliferation, apoptosis and fuel utilization.
Keywords:
Nr4a1; Nr4a2; Nr4a3; apoptosis; fuel utilization; metabolism; nuclear hormone receptors; proliferation.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Apoptosis / physiology
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Cell Nucleus / metabolism
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Cell Proliferation / physiology
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DNA-Binding Proteins / metabolism
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Energy Metabolism / physiology
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Humans
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Inflammation / metabolism
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Nerve Tissue Proteins / metabolism
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Nuclear Receptor Subfamily 4, Group A, Member 1 / metabolism
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Nuclear Receptor Subfamily 4, Group A, Member 2 / metabolism
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Organ Specificity
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Orphan Nuclear Receptors / metabolism*
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Receptors, Steroid / metabolism
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Receptors, Thyroid Hormone / metabolism
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Signal Transduction / physiology
Substances
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DNA-Binding Proteins
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NR4A1 protein, human
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NR4A2 protein, human
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NR4A3 protein, human
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Nerve Tissue Proteins
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Nuclear Receptor Subfamily 4, Group A, Member 1
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Nuclear Receptor Subfamily 4, Group A, Member 2
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Orphan Nuclear Receptors
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Receptors, Steroid
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Receptors, Thyroid Hormone