A flavonoid-based fluorescent probe enables the accurate quantification of human serum albumin by minimizing the interference from blood lipids

Kangning Zhu; Taoyuze Lv; Tianyi Qin; Yingying Huang; Lei Wang; Bin Liu

doi:10.1039/c9cc08015e

A flavonoid-based fluorescent probe enables the accurate quantification of human serum albumin by minimizing the interference from blood lipids

Chem Commun (Camb). 2019 Dec 4;55(93):13983-13986. doi: 10.1039/c9cc08015e. Epub 2019 Nov 5.

Authors

Kangning Zhu¹, Taoyuze Lv², Tianyi Qin², Yingying Huang², Lei Wang², Bin Liu²

Affiliations

¹ Shenzhen Key Laboratory of Polymer Science and Technology, College of Materials Science and Engineering, Shenzhen University, Shenzhen, 518060, P. R. China. [email protected] and Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, 325001, P. R. China.
² Shenzhen Key Laboratory of Polymer Science and Technology, College of Materials Science and Engineering, Shenzhen University, Shenzhen, 518060, P. R. China. [email protected].

PMID: 31687687
DOI: 10.1039/c9cc08015e

Abstract

We herein provide a simple design strategy to improve the sensing specificity towards human serum albumin by incorporating a nitrobenzene quencher into a traditional polarity-sensitive probe in responding to the interference from blood lipids.

MeSH terms

Flavonoids / chemistry*
Flavonoids / metabolism
Fluorescent Dyes / chemistry*
Fluorescent Dyes / metabolism
Humans
Lipids / blood
Lipids / chemistry*
Molecular Docking Simulation
Nitrobenzenes / chemistry
Nitrobenzenes / metabolism
Proof of Concept Study
Protein Binding
Serum Albumin, Human / analysis*
Serum Albumin, Human / metabolism
Spectrometry, Fluorescence

Substances

Flavonoids
Fluorescent Dyes
Lipids
Nitrobenzenes
Serum Albumin, Human