p16INK4A (hereafter called p16) is a faithful cellular ally in the fight against tumorigenesis. Although its canonical pathway through retinoblastoma (RB) is well delineated, RB-independent functions for p16 are beginning to emerge. Here we summarize non-canonical roles of p16, including our recent finding on its role in nucleotide metabolism.
Keywords: AP-1; JNK1/3; NF-κB; Retinoblastoma; SP1; cell cycle; mTORC1; nucleotide metabolism; reactive oxygen species; senescence.
© 2019 The Author(s). Published by Taylor & Francis.