Persistence of HIV reservoir following successful haematopoietic stem cell transplant for juvenile myelomonocytic leukaemia in a child with perinatally acquired HIV

G Dobson; N Klein; P Veys; W Qasim; J Silva; I L Cheng; D Shingadia; G Tudor-Williams; S A Watters; H Lyall; A Rao; C Foster; A Bamford

doi:10.1016/S2055-6640(20)30048-0

Persistence of HIV reservoir following successful haematopoietic stem cell transplant for juvenile myelomonocytic leukaemia in a child with perinatally acquired HIV

J Virus Erad. 2019 Sep 18;5(3):174-177. doi: 10.1016/S2055-6640(20)30048-0.

Authors

G Dobson¹, N Klein^{1

2}, P Veys^{2

3}, W Qasim^{2

4}, J Silva³, I L Cheng⁵, D Shingadia^{1

2}, G Tudor-Williams^{6

7}, S A Watters², H Lyall⁶, A Rao⁸, C Foster⁶, A Bamford^{1

2}

Affiliations

¹ Paediatric Infectious Diseases Department, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.
² UCL Great Ormond Street Institute of Child Health, London, UK.
³ Paediatric Bone Marrow Transplant Department, Great Ormond Street Hospital NHS Foundation Trust, London, UK.
⁴ Paediatric Immunology Department, Great Ormond Street Hospital NHS Foundation Trust, London, UK.
⁵ Paediatric Pharmacy Department, Great Ormond Street Hospital NHS Foundation Trust, London, UK.
⁶ Paediatric Infectious Diseases Department, St Mary's Hospital, Imperial College Healthcare NHS Foundation Trust, London, UK.
⁷ Division of Infectious Diseases, Imperial College London, London, UK.
⁸ Paediatric Haematology Department, Great Ormond Street Hospital NHS Foundation Trust, London, UK.

Abstract

This report describes a case of juvenile myelomonocytic leukaemia (JMML) on a background of both perinatally acquired HIV infection and congenital cytomegalovirus, and management of antiretroviral therapy during haematopoietic stem cell transplant. Peripheral blood HIV viral load remained below the lower limit of detection throughout and following transplant and is currently <20 RNA copies/mL. The child is currently in remission from JMML, but HIV DNA remains detectable despite myeloablative conditioning and sustained plasma HIV viral suppression.

Publication types

Editorial