Coronary artery disease in a child with homozygous familial hypercholesterolemia: Regression after liver transplantation

J Clin Lipidol. 2019 Nov-Dec;13(6):880-886. doi: 10.1016/j.jacl.2019.09.007. Epub 2019 Sep 25.

Abstract

Children with homozygous familial hypercholesterolemia are at risk for early cardiovascular events secondary to coronary artery disease. Current medical therapy does not ameliorate this risk. Liver transplantation offers the most effective option to reduce circulating levels of low-density lipoprotein cholesterol and thereby reduce risk of cardiovascular events. Angiographic evidence of regression of coronary artery disease is presented.

Keywords: Angiogram; Cardiac catheterization; Coronary atherosclerosis; Genetic; LDL receptor; Liver transplantation; Pediatric; Regression; Treatment.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Cardiac Catheterization
  • Child, Preschool
  • Coronary Artery Disease / diagnosis*
  • Coronary Artery Disease / metabolism*
  • Female
  • Humans
  • Hyperlipoproteinemia Type II / etiology
  • Hyperlipoproteinemia Type II / metabolism*
  • Hyperlipoproteinemia Type II / pathology*
  • Liver Transplantation*
  • Male
  • Pedigree
  • Receptors, LDL / genetics
  • Receptors, LDL / metabolism
  • Young Adult

Substances

  • Receptors, LDL