Efficacy of Retreatment After Failed Direct-acting Antiviral Therapy in Patients With HCV Genotype 1-3 Infections

Julia Dietz; Ulrich Spengler; Beat Müllhaupt; Julian Schulze Zur Wiesch; Felix Piecha; Stefan Mauss; Barbara Seegers; Holger Hinrichsen; Christoph Antoni; Perdita Wietzke-Braun; Kai-Henrik Peiffer; Annemarie Berger; Katrin Matschenz; Peter Buggisch; Johanna Backhus; Eugen Zizer; Tobias Boettler; Christoph Neumann-Haefelin; David Semela; Rudolf Stauber; Thomas Berg; Christoph Berg; Stefan Zeuzem; Johannes Vermehren; Christoph Sarrazin; European HCV Resistance Study Group

doi:10.1016/j.cgh.2019.10.051

Efficacy of Retreatment After Failed Direct-acting Antiviral Therapy in Patients With HCV Genotype 1-3 Infections

Clin Gastroenterol Hepatol. 2021 Jan;19(1):195-198.e2. doi: 10.1016/j.cgh.2019.10.051. Epub 2019 Nov 6.

Authors

Julia Dietz¹, Ulrich Spengler², Beat Müllhaupt³, Julian Schulze Zur Wiesch⁴, Felix Piecha⁴, Stefan Mauss⁵, Barbara Seegers⁶, Holger Hinrichsen⁶, Christoph Antoni⁷, Perdita Wietzke-Braun⁸, Kai-Henrik Peiffer¹, Annemarie Berger⁹, Katrin Matschenz¹⁰, Peter Buggisch¹⁰, Johanna Backhus¹¹, Eugen Zizer¹¹, Tobias Boettler¹², Christoph Neumann-Haefelin¹², David Semela¹³, Rudolf Stauber¹⁴, Thomas Berg¹⁵, Christoph Berg¹⁶, Stefan Zeuzem¹, Johannes Vermehren¹, Christoph Sarrazin¹⁷; European HCV Resistance Study Group

Collaborators

European HCV Resistance Study Group:
J Balavoine, E Giostra, M Berning, J Hampe, A De Gottardi, A Rauch, N Semmo, T Discher, J Trauth, J Fischer, M Gress, R Günther, H Heinzow, J Schmidt, A Herrmann, A Stallmach, G Hilgard, K Deterding, C M Lange, S Ciesek, H Wedemeyer, D Hoffmann, H Klinker, P Schulze, F Kocheise, M Müller-Schilling, A Kodal, A Kremer, M Ganslmayer, J Siebler, F Lammert, J Rissland, M Löbermann, T Götze, A Canbay, A Lohse, J von Felden, S Jordan, A Maieron, D Moradpour, J-P Chave, C Moreno, T Müller, M Muche, H-J Epple, K Port, T von Hahn, M Cornberg, M Manns, L Reinhardt, V Ellenrieder, J Rockstroh, J Schattenberg, M Sprinzl, P Galle, E Roeb, M Steckstor, W Schmiegel, N H Brockmeyer, T Seufferlein, W Stremmel, B Strey, R Thimme, A Teufel, R Vogelmann, M Ebert, K Tomasiewicz, C Trautwein, F Tacke, T Koenen, T Weber, R Zachoval, J Mayerle, B Raziorrouh, W Angeli, S Beckebaum, C Doberauer, E Durmashkina, A Hackelsberger, A Erhardt, A Garrido-Lüneburg, H Gattringer, D Genné, M Gschwantler, F Gundling, S Hametner, R Schöfl, C Hartmann, T Heyer, C Hirschi, A Jussios, S Kanzler, N Kordecki, M Kraus, U Kullig, S Wollschläger, L Magenta, B Terziroli Beretta-Piccoli, M Menges, L Mohr, K Muehlenberg, C Niederau, B Paulweber, A Petrides, M Pinkernell, R Piso, W Rambach, M Reiser, B Riecken, A Rieke, J Roth, M Schelling, P Schlee, A Schneider, D Scholz, E Schott, M Schuchmann, U Schulten-Baumer, A Seelhoff, A Stich, F Stickel, J Ungemach, E Walter, A Weber, T Winzer, W Abels, M Adler, F Audebert, C Baermann, E Bästlein, R Barth, K Barthel, W Becker, J Behrends, J Benninger, F Berger, D Berzow, T Beyer, M Bierbaum, O Blaukat, A Bodtländer, G Böhm, N Börner, U Bohr, B Bokemeyer, H R Bruch, D Bucholz, O Burkhard, N Busch, C Chirca, R Delker, J Diedrich, M Frank, M Diehl, A Dienethal, P Dietel, N Dikopoulos, M Dreck, F Dreher, L Drude, K Ende, U Ehrle, K Baumgartl, F Emke, R Glosemeyer, G Felten, D Hüppe, J Fischer, U Fischer, D Frederking, B Frick, G Friese, B Gantke, P Geyer, H R Schwind, M Glas, T Glaunsinger, F Goebel, U Göbel, B Görlitz, R Graf, H Gruber, G Härter, M Herder, T Heuchel, S Heuer, K-H Höffl, H Hörster, J-U Sonne, W P Hofmann, F Holst, M Hunstiger, A Hurst, E Jägel-Guedes, C John, M Jung, B Kallinowski, B Kapzan, W Kerzel, P Khaykin, M Klarhof, U Klüppelberg, K Klugewitz, B Knapp, U Knevels, T Kochsiek, A Körfer, A Köster, M Kuhn, A Langekamp, B Künzig, R Link, M Littman, H Löhr, T Lutz, G Knecht, U Lutz, D Mainz, I Mahle, P Maurer, C Mayer, V Meister, H Möller, R Heyne, D Moritzen, M Mroß, M Mundlos, U Naumann, O Nehls, K R Ningel, A Oelmann, H Olejnik, K Gadow, E Pascher, J Petersen, A Philipp, M Pichler, F Polzien, R Raddant, M Riedel, S Rietzler, M Rössle, W Rufle, A Rump, C Schewe, C Hoffmann, D Schleehauf, K J Schmidt, W Schmidt, G Schmidt-Heinevetter, J Schmidtler-von Fabris, E Schnaitmann, L Schneider, A Schober, S Niehaus-Hahn, J Schwenzer, T Seidel, G Seitel, C Sick, K G Simon, D Stähler, F Stenschke, H Steffens, K Stein, M Steinmüller, T Sternfeld, B Strey, K Svensson, W Tacke, G Teuber, K Teubner, J Thieringer, A Tomesch, U Trappe, J Ullrich, G Urban, S Usadel, A von Lucadou, F Weinberger, M Werheid-Dobers, P Werner, T Winter, E Zehnter, A Zipf

Affiliations

¹ Department of Internal Medicine 1, University Hospital Frankfurt, Goethe University, Frankfurt, and German Center for Infection Research (DZIF), External Partner Site, Frankfurt, Germany.
² Department of Internal Medicine I, University of Bonn, Bonn, and German Center for Infection Research (DZIF), Partner Site, Cologne-Bonn, Germany.
³ Swiss Hepato-Pancreato-Biliary Center and Department of Gastroenterology and Hepatology, University Hospital Zürich, Zürich, Switzerland.
⁴ I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, and German Center for Infection Research (DZIF), Partner Site, Hamburg-Lübeck-Borstel-Riems, Germany.
⁵ Center for HIV and Hepatogastroenterology, Düsseldorf, Germany.
⁶ Gastroenterologisch-Hepatologisches Zentrum Kiel, Kiel, Germany.
⁷ Department of Internal Medicine II, University Hospital Mannheim, Mannheim, Germany.
⁸ Medical Department I, University Hospital Schleswig-Holstein, Kiel, Germany.
⁹ Institute for Medical Virology, University Hospital Frankfurt, Frankfurt, Germany.
¹⁰ Institute for Interdisciplinary Medicine IFI, Hamburg, Germany.
¹¹ Department of Internal Medicine I, Ulm University, Ulm, Germany.
¹² Department of Medicine II, Medical Center, University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
¹³ Division of Gastroenterology and Hepatology, Kantonsspital St Gallen, St Gallen, Switzerland.
¹⁴ Department of Internal Medicine, Medical University of Graz, Graz, Austria.
¹⁵ Department of Gastroenterology and Rheumatology, University Hospital Leipzig, Leipzig, Germany.
¹⁶ Department of Internal Medicine I, University of Tübingen, Tübingen, Germany.
¹⁷ Department of Internal Medicine 1, University Hospital Frankfurt, Goethe University, Frankfurt, and German Center for Infection Research (DZIF), External Partner Site, Frankfurt, Germany; Medizinische Klinik 2, St Josefs-Hospital, Wiesbaden, Germany. Electronic address: [email protected].

PMID: 31706062
DOI: 10.1016/j.cgh.2019.10.051

Abstract

Hepatitis C virus infection is causing chronic liver disease, cirrhosis, and hepatocellular carcinoma. By combining direct-acting antivirals (DAAs), high sustained virologic response rates (SVRs) can be achieved. Resistance-associated substitutions (RASs) are commonly observed after DAA failure, and especially nonstructural protein 5A (NS5A) RASs may impact retreatment options.^1-3 Data on retreatment of DAA failure patients using first-generation DAAs are limited.^4-7 Recently, a second-generation protease- and NS5A-inhibitor plus sofosbuvir (voxilaprevir/velpatasvir/sofosbuvir [VOX/VEL/SOF]) was approved for retreatment after DAA failure.⁸ However, this and other second-generation regimens are not available in many resource-limited countries or are not reimbursed by regular insurance, and recommendations regarding the selection of retreatment regimens using first-generation DAAs are very important. This study aimed to analyze patients who were re-treated with first-generation DAAs after failure of a DAA combination therapy.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antiviral Agents / therapeutic use
Drug Resistance, Viral
Drug Therapy, Combination
Genotype
Hepacivirus / genetics
Hepatitis C* / drug therapy
Hepatitis C, Chronic* / drug therapy
Humans
Liver Neoplasms* / drug therapy
Retreatment
Sofosbuvir / therapeutic use
Sustained Virologic Response
Viral Nonstructural Proteins / genetics

Substances

Antiviral Agents
Viral Nonstructural Proteins
Sofosbuvir