The Kidney Biopsy in Systemic Lupus Erythematosus: A View of the Past and a Vision of the Future

Adv Chronic Kidney Dis. 2019 Sep;26(5):360-368. doi: 10.1053/j.ackd.2019.08.015.

Abstract

The kidney biopsy advanced our understanding of kidney disease in systemic lupus erythematosus. It allowed for better recognition and classification of lupus nephritis (LN). Several LN classifications have been devised in an effort to inform treatment decision and predict prognosis, and these are being further updated. In this review, we will examine the role of diagnostic as well as repeat kidney biopsy in the management of LN, including the potential role of molecular interrogation as a step forward beyond conventional histology to guide the discovery of novel biomarkers and a precision medicine approach to the management of LN.

Keywords: Histology; Kidney biopsy; Lupus nephritis; Molecular pathology; Systemic lupus erythematosus.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Biopsy / trends*
  • Humans
  • Kidney / pathology*
  • Lupus Erythematosus, Systemic* / complications
  • Lupus Erythematosus, Systemic* / pathology
  • Lupus Nephritis* / classification
  • Lupus Nephritis* / diagnosis
  • Pathology, Molecular / methods*
  • Prognosis