The Utility of PET/Computed Tomography for Radiation Oncology Planning, Surveillance, and Prognosis Prediction of Gastrointestinal Tumors

Stephanie R Rice; Michael Chuong; Antony Koroulakis; Osman M Siddiqui; Ankur M Sharma; Charles B Simone 2nd; Jason K Molitoris; Adeel Kaiser

doi:10.1016/j.cpet.2019.08.004

The Utility of PET/Computed Tomography for Radiation Oncology Planning, Surveillance, and Prognosis Prediction of Gastrointestinal Tumors

PET Clin. 2020 Jan;15(1):77-87. doi: 10.1016/j.cpet.2019.08.004. Epub 2019 Oct 29.

Authors

Stephanie R Rice¹, Michael Chuong², Antony Koroulakis¹, Osman M Siddiqui¹, Ankur M Sharma³, Charles B Simone 2nd⁴, Jason K Molitoris⁵, Adeel Kaiser⁶

Affiliations

¹ Department of Radiation Oncology, University of Maryland Medical Center, 22 S. Greene Street, Baltimore, MD, USA.
² Department of Radiation Oncology, Miami Cancer Institute, 8900 Kendall Drive, Miami, FL, USA.
³ Department of Radiation Oncology, Maryland Proton Treatment Center, University of Maryland School of Medicine, 850 West Baltimore Street, Baltimore, MD, USA; Harvard T.H. Chan School of Public Health, Harvard University, 677 Huntington Avenue, Boston, MA, USA.
⁴ New York Proton Center, 225 East 126th Street, New York, NY, USA.
⁵ Department of Radiation Oncology, University of Maryland School of Medicine, 22 S. Greene Street, Baltimore, MD, USA.
⁶ Department of Radiation Oncology, University of Maryland School of Medicine, 22 S. Greene Street, Baltimore, MD, USA. Electronic address: [email protected].

PMID: 31735304
DOI: 10.1016/j.cpet.2019.08.004

Abstract

At present, the strongest evidence for the use of PET/computed tomography (CT) in gastrointestinal (GI) malignancies is to rule out distant metastatic disease at diagnosis, radiation treatment planning for anal malignancies, and disease recurrence monitoring in colorectal and anal malignancies. Use of PET/CT for GI malignancies continues to evolve over time, with new studies evaluating prognostic abilities of PET/CT and with increasing sensitivity and spatial resolution of more modern PET/CT scanners. The authors encourage future applications and prospective evaluation of the use of PET/CT in the staging, prognostication, and recurrence prediction for GI malignancies.

Keywords: Gastrointestinal; PET/CT; Prognosis; Staging.

Publication types

Review

MeSH terms

Gastrointestinal Neoplasms / diagnostic imaging*
Gastrointestinal Neoplasms / radiotherapy
Humans
Neoadjuvant Therapy
Neoplasm Recurrence, Local / diagnostic imaging
Neoplasm Staging
Patient Care Planning
Positron Emission Tomography Computed Tomography / methods*
Postoperative Care / methods
Prognosis