Substances released during tetanic stimulation of rabbit neocortex induce neurite growth in PC-12 cells and long-term potentiation in guinea pig hippocampus

Neurosci Lett. 1988 Aug 15;91(1):101-5. doi: 10.1016/0304-3940(88)90256-x.

Abstract

Samples collected from rabbit neocortical surface during a tetanic stimulation of the neocortex induced neurite growth in PC-12 cells in culture and synaptic long-term potentiation (LTP) in guinea pig hippocampal slices. If these samples were preheated and cooled, or if they were collected in the absence of a tetanic stimulation of the rabbit neocrotex, they did not induce neurite growth in PC-12 cells or LTP in the guinea pig hippocampus. These results suggest that neurite-inducing factors are released during tetanic stimulations and that these substances are involved in LTP.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Action Potentials / drug effects
  • Animals
  • Cells, Cultured
  • Cerebral Cortex / metabolism*
  • Cerebral Cortex / physiology
  • Electric Stimulation
  • Evoked Potentials
  • Guinea Pigs
  • Hippocampus / drug effects
  • Hippocampus / physiology*
  • Nerve Growth Factors*
  • Peptides / metabolism*
  • Peptides / pharmacology
  • Pheochromocytoma
  • Rabbits
  • Rats
  • Tumor Cells, Cultured / drug effects
  • Tumor Cells, Cultured / physiology*

Substances

  • Nerve Growth Factors
  • Peptides
  • neurite-inducing factor