Fat/Dachsous family cadherins in cell and tissue organisation

Alexander D Fulford; Helen McNeill

doi:10.1016/j.ceb.2019.10.006

Fat/Dachsous family cadherins in cell and tissue organisation

Curr Opin Cell Biol. 2020 Feb:62:96-103. doi: 10.1016/j.ceb.2019.10.006. Epub 2019 Nov 15.

Authors

Alexander D Fulford¹, Helen McNeill²

Affiliations

¹ Department of Developmental Biology, Washington University School of Medicine, St Louis, MO 63110, USA.
² Department of Developmental Biology, Washington University School of Medicine, St Louis, MO 63110, USA; Lunenfeld-Tanenbaum Research Institute, Sinai Health Systems, Toronto, Canada; Department of Molecular Genetics, University of Toronto, Toronto, Canada. Electronic address: [email protected].

PMID: 31739265
DOI: 10.1016/j.ceb.2019.10.006

Abstract

Precisely controlled organisation at the cellular and tissue level is crucial to establish and maintain complex organisms. The atypical cadherins Fat (Ft), Fat2 and Dachsous (Ds) contribute to this organisation by regulating growth and planar cell polarity. Here we describe the recent advances in understanding how these large cadherins coordinate these processes, and discuss additional progress extending their function in regulation of microtubules, migration and disease.

Keywords: Dachsous; Fat; Hippo signalling; Planar cell polarity.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Cadherins / metabolism*
Cadherins / physiology
Cell Polarity / physiology*
Drosophila Proteins / physiology*

Substances

Cadherins
Drosophila Proteins
ds protein, Drosophila
kug protein, Drosophila

Grants and funding

CIHR/Canada