Travelling Together: A Unifying Pathomechanism for ALS

Trends Neurosci. 2020 Jan;43(1):1-2. doi: 10.1016/j.tins.2019.10.006. Epub 2019 Nov 16.

Abstract

Axonal transport is critical for neuronal homeostasis and relies on motor complexes bound to cargoes via specific adaptors. However, the mechanisms responsible for the spatiotemporal regulation of axonal transport are not completely understood. A recent study by Liao et al. contributes to filling this gap by reporting that RNA granules 'hitchhike' on LAMP1-positive organelles using annexin A11 as a tether.

Keywords: LAMP1-positive organelles; RNA granules; amyotrophic lateral sclerosis; annexin A11; axonal transport.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Amyotrophic Lateral Sclerosis*
  • Annexins* / metabolism
  • Axonal Transport
  • Humans
  • Lysosomes / metabolism
  • Organelles
  • RNA

Substances

  • Annexins
  • RNA

Supplementary concepts

  • Amyotrophic Lateral Sclerosis 2, Juvenile