Role of Indoleamine-2,3-Dioxygenase Inhibitors in Salvage Therapy for Non-Muscle Invasive Bladder Cancer

Carissa E Chu; Sima P Porten; Gary D Grossfeld; Maxwell V Meng

doi:10.1016/j.ucl.2019.09.013

Role of Indoleamine-2,3-Dioxygenase Inhibitors in Salvage Therapy for Non-Muscle Invasive Bladder Cancer

Urol Clin North Am. 2020 Feb;47(1):111-118. doi: 10.1016/j.ucl.2019.09.013.

Authors

Carissa E Chu¹, Sima P Porten¹, Gary D Grossfeld², Maxwell V Meng³

Affiliations

¹ Department of Urology, University of California, San Francisco, 550 16th Street, 6th Floor, San Francisco, CA 94143, USA.
² Bristol-Myers Squibb, 3401 Princeton Pike, Lawrenceville, New Jersey 08648, USA.
³ Department of Urology, University of California, San Francisco, 550 16th Street, 6th Floor, San Francisco, CA 94143, USA. Electronic address: [email protected].

PMID: 31757294
DOI: 10.1016/j.ucl.2019.09.013

Abstract

Due to significant risks of cancer recurrence and progression, and limited options after intravesical Bacillus Calmette Guerin (BCG) therapy, there is a critical unmet need to identify novel treatments for those patients with BCG-unresponsive bladder cancer. There is active investigation of immunotherapies which provide both biologic and clinical rationales for indoleamine-2,3- dioxygenase inhibitors in salvage therapy for non-muscle invasive bladder cancer.

Keywords: BCG-unresponsive; IDO inhibitors; Non–muscle invasive bladder cancer.

Publication types

Review

MeSH terms

Acetamides / administration & dosage*
Administration, Intravesical
Enzyme Inhibitors / administration & dosage
Humans
Indoleamine-Pyrrole 2,3,-Dioxygenase / antagonists & inhibitors*
Neoplasm Invasiveness
Oximes / administration & dosage*
Quinolines / administration & dosage*
Salvage Therapy / methods*
Sulfonamides / administration & dosage*
Treatment Outcome
Tryptophan / administration & dosage
Tryptophan / analogs & derivatives*
Tryptophan Oxygenase
Urinary Bladder Neoplasms / immunology
Urinary Bladder Neoplasms / pathology
Urinary Bladder Neoplasms / therapy*

Substances

Acetamides
Enzyme Inhibitors
Indoleamine-Pyrrole 2,3,-Dioxygenase
Oximes
Quinolines
Sulfonamides
linrodostat
epacadostat
Tryptophan
Tryptophan Oxygenase
1-methyltryptophan