PGL-1 and LID-1 antibody levels in HIV-infected and HIV-uninfected individuals in a Hansen's disease (leprosy) endemic area of Brazil

Immunobiology. 2020 Jan;225(1):151866. doi: 10.1016/j.imbio.2019.11.001. Epub 2019 Nov 10.

Abstract

Serological tests for subclinical Mycobacterium leprae infection based on antibodies to phenolic glycolipid-1 (PGL-1) and leprosy IDRI diagnostic-1 (LID-1) have not been compared in HIV-infected and uninfected individuals. PGL-1 seropositivity by ELISA was 6.0 % (21/350) in HIV-infected compared with 29.1 % (102/350) in HIV-uninfected individuals (p < 0.001); LID-1 seropositivity was 45.4 % (159/350) in HIV-infected compared with 50.3 % (153/304) in HIV-uninfected individuals (p = 0.21). In HIV-infected individuals, LID-1 but not PGL-1 antibody levels were inversely associated with CD4+ cell count (p = 0.02). These differential associations of HIV infection and CD4 count with PGL-1 and LID-1 have implications for M leprae immunodiagnostic tools and require replication.

Keywords: HIV; LID-1; Leprosy; PGL-1.

MeSH terms

  • Adult
  • Antibodies, Bacterial / blood*
  • Antibody Formation
  • Antigens, Bacterial / immunology
  • Brazil / epidemiology
  • CD4-Positive T-Lymphocytes / immunology*
  • Cell Count
  • Endemic Diseases
  • Female
  • Glycolipids / immunology
  • HIV Infections / diagnosis
  • HIV Infections / epidemiology
  • HIV Infections / immunology*
  • HIV-1 / physiology*
  • Humans
  • Immunologic Tests
  • Leprosy / diagnosis
  • Leprosy / epidemiology
  • Leprosy / immunology*
  • Lipid Droplet Associated Proteins / immunology
  • Male
  • Mycobacterium leprae / physiology*
  • Young Adult

Substances

  • Antibodies, Bacterial
  • Antigens, Bacterial
  • Glycolipids
  • Lipid Droplet Associated Proteins
  • phenolic glycolipid I, Mycobacterium leprae