UV-responsive AKBA@ZnO nanoparticles potential for polymorphous light eruption protection and therapy

Xiao Huang; Muhammad Farrukh Nisar; Mei Wang; Wenhong Wang; Long Chen; Mao Lin; Wei Xu; Qingchun Diao; Julia Li Zhong

doi:10.1016/j.msec.2019.110254

UV-responsive AKBA@ZnO nanoparticles potential for polymorphous light eruption protection and therapy

Mater Sci Eng C Mater Biol Appl. 2020 Feb:107:110254. doi: 10.1016/j.msec.2019.110254. Epub 2019 Oct 14.

Authors

Xiao Huang¹, Muhammad Farrukh Nisar², Mei Wang², Wenhong Wang³, Long Chen², Mao Lin⁴, Wei Xu⁴, Qingchun Diao⁴, Julia Li Zhong⁵

Affiliations

¹ Key Laboratory of Biorheological Science and Technology, Ministry of Education, Bioengineering College, Chongqing University, Chongqing, 400044, China; Institute of Nanomedicine and Biomaterials, School of Sports and Health Science, Tongren University, Tongren, 554300, China; Guizhou Provincical College-based Key Lab for Tumor Prevention and Treatment with Distinctive Medicines, Zunyi Medical University, Zunyi, 563003, China. Electronic address: [email protected].
² Key Laboratory of Biorheological Science and Technology, Ministry of Education, Bioengineering College, Chongqing University, Chongqing, 400044, China.
³ Institute of Nanomedicine and Biomaterials, School of Sports and Health Science, Tongren University, Tongren, 554300, China; Guizhou Provincical College-based Key Lab for Tumor Prevention and Treatment with Distinctive Medicines, Zunyi Medical University, Zunyi, 563003, China.
⁴ Department of Dermatology, Chongqing First People's Hospital and Chongqing Traditional Chinese Medicine Hospital, Chongqing, 400011, China.
⁵ Key Laboratory of Biorheological Science and Technology, Ministry of Education, Bioengineering College, Chongqing University, Chongqing, 400044, China; Department of Dermatology, Chongqing First People's Hospital and Chongqing Traditional Chinese Medicine Hospital, Chongqing, 400011, China. Electronic address: [email protected].

PMID: 31761216
DOI: 10.1016/j.msec.2019.110254

Abstract

Polymorphous light eruption (PLE) is one of the acquired idiopathic photodermatosis mainly induced by immoderate UV radiation. In order to realize UV protection and medicine administration simultaneously for polymorphous light eruption protection and therapy, Acetyl-11-keto-β-boswellic acid (AKBA) loaded Zinc Oxide (ZnO) nanoparticles of which drug release behavior is UV-controlled has been successfully synthesized. Such nanoparticles can not only reflect UV but also transfer the energy to release AKBA which presents an excellent antioxidant and anti-inflammatory effects. In addition, they are biocompatible to HaCaT cells. As a result, they have a great potential in combining UV protection and medicine administration simultaneously for PLE protection and therapy.

Keywords: AKBA; PLE; Prevention and treatment integrated; UV radiation; ZnO.

MeSH terms

Anti-Inflammatory Agents / chemistry
Anti-Inflammatory Agents / metabolism
Anti-Inflammatory Agents / pharmacology
Antioxidants / chemistry
Biocompatible Materials / chemistry
Biocompatible Materials / metabolism
Biocompatible Materials / pharmacology
Cell Line
Cell Survival / drug effects
Cyclooxygenase 2 / genetics
Cyclooxygenase 2 / metabolism
Drug Liberation
Humans
Keratinocytes / cytology
Keratinocytes / drug effects
Keratinocytes / metabolism
Nanoparticles / chemistry*
Nanoparticles / toxicity
Photosensitivity Disorders / pathology
Photosensitivity Disorders / prevention & control
Reactive Oxygen Species
Triterpenes / chemistry*
Triterpenes / metabolism
Triterpenes / pharmacology
Ultraviolet Rays*
Zinc Oxide / chemistry*

Substances

Anti-Inflammatory Agents
Antioxidants
Biocompatible Materials
Reactive Oxygen Species
Triterpenes
acetyl-11-ketoboswellic acid
Cyclooxygenase 2
Zinc Oxide