Ultrasound accelerated synthesis of O-alkylated hydroximides under solvent- and metal-free conditions

Hongmei Jiang; Xiaoyue Tang; Sihan Liu; Lian Wang; Haicheng Shen; Jiankui Yang; Huixian Wang; Qing-Wen Gui

doi:10.1039/c9ob02245g

Ultrasound accelerated synthesis of O-alkylated hydroximides under solvent- and metal-free conditions

Org Biomol Chem. 2019 Dec 28;17(48):10223-10227. doi: 10.1039/c9ob02245g. Epub 2019 Nov 28.

Authors

Hongmei Jiang¹, Xiaoyue Tang², Sihan Liu³, Lian Wang³, Haicheng Shen³, Jiankui Yang³, Huixian Wang³, Qing-Wen Gui³

Affiliations

¹ College of Science, Hunan Agricultural University, Changsha 410128, People's Republic of China. [email protected] [email protected] and State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemical Engineering, Hunan University, Changsha 410082, People's Republic of China.
² Department of Pharmaceutical Engineering, School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640, People's Republic of China.
³ College of Science, Hunan Agricultural University, Changsha 410128, People's Republic of China. [email protected] [email protected].

PMID: 31777898
DOI: 10.1039/c9ob02245g

Abstract

A novel, sustainable, environmentally friendly, high substrate scope, efficient, solvent-free and metal catalyst-free method for the cross-dehydrogenative coupling (CDC) reaction between N-hydroxyphthalimide (NHPI) and benzyl/ether compounds is described. This coupling reaction proceeds through ultrasound acceleration. Compared to conventional heating conditions, the use of ultrasound techniques not only improves the reaction efficiency and enhances the reaction rate but also minimizes the side reactions.

Publication types

Research Support, Non-U.S. Gov't