Substance related disorders are associated with impaired valuation of delayed gratification and feedback processing: A multilevel meta-analysis and meta-regression

B Kluwe-Schiavon; T W Viola; B Sanvicente-Vieira; F S Lumertz; G A Salum; R Grassi-Oliveira; B B Quednow

doi:10.1016/j.neubiorev.2019.11.016

Substance related disorders are associated with impaired valuation of delayed gratification and feedback processing: A multilevel meta-analysis and meta-regression

Neurosci Biobehav Rev. 2020 Jan:108:295-307. doi: 10.1016/j.neubiorev.2019.11.016. Epub 2019 Nov 25.

Authors

B Kluwe-Schiavon¹, T W Viola², B Sanvicente-Vieira³, F S Lumertz⁴, G A Salum⁵, R Grassi-Oliveira⁶, B B Quednow⁷

Affiliations

¹ Experimental and Clinical Pharmacopsychology, Department of Psychiatry, Psychotherapy, and Psychosomatics, Psychiatric Hospital, University of Zurich, Lenggstrasse 31, CH-8032, Zurich, Switzerland; Developmental Cognitive Neuroscience Laboratory, Brain Institute, Pontifical Catholic University of Rio Grande do Sul, Pontifical Catholic University of Rio Grande do Sul, Ipiranga Avenue, 6681, 11, 936. Partenon, 90619-900, Porto Alegre, RS, Brazil. Electronic address: [email protected].
² Developmental Cognitive Neuroscience Laboratory, Brain Institute, Pontifical Catholic University of Rio Grande do Sul, Pontifical Catholic University of Rio Grande do Sul, Ipiranga Avenue, 6681, 11, 936. Partenon, 90619-900, Porto Alegre, RS, Brazil. Electronic address: [email protected].
³ Developmental Cognitive Neuroscience Laboratory, Brain Institute, Pontifical Catholic University of Rio Grande do Sul, Pontifical Catholic University of Rio Grande do Sul, Ipiranga Avenue, 6681, 11, 936. Partenon, 90619-900, Porto Alegre, RS, Brazil. Electronic address: [email protected].
⁴ Developmental Cognitive Neuroscience Laboratory, Brain Institute, Pontifical Catholic University of Rio Grande do Sul, Pontifical Catholic University of Rio Grande do Sul, Ipiranga Avenue, 6681, 11, 936. Partenon, 90619-900, Porto Alegre, RS, Brazil. Electronic address: [email protected].
⁵ Hospital de Clínicas de Porto Alegre, Federal University of Rio Grande do Sul, Hospital de Clínicas de Porto Alegre, Ramiro Barcelos Street, 2350 - Santa Cecilia, Porto Alegre, RS 90035-007, Brazil. Electronic address: [email protected].
⁶ Developmental Cognitive Neuroscience Laboratory, Brain Institute, Pontifical Catholic University of Rio Grande do Sul, Pontifical Catholic University of Rio Grande do Sul, Ipiranga Avenue, 6681, 11, 936. Partenon, 90619-900, Porto Alegre, RS, Brazil. Electronic address: [email protected].
⁷ Experimental and Clinical Pharmacopsychology, Department of Psychiatry, Psychotherapy, and Psychosomatics, Psychiatric Hospital, University of Zurich, Lenggstrasse 31, CH-8032, Zurich, Switzerland; Neuroscience Center Zurich, University of Zurich and Swiss Federal Institute of Technology Zurich, Rämistrasse 101, CH-8092 Zürich, Switzerland. Electronic address: [email protected].

PMID: 31778679
DOI: 10.1016/j.neubiorev.2019.11.016

Abstract

Across numerous studies, individuals with substance use disorders (SUDs) differed from non-using controls regarding valuation of delayed gratification and feedback processing. However, it remains unclear whether the magnitude of the effect sizes is different across these two cognitive processes and how specific SUDs as well as demographic and clinical moderators influence these effects. In this study we thus performed multilevel linear mixed-effects meta-analyses and meta-regressions to examine the effects of SUDs on the Delay Discounting Task (DD) and on the Iowa Gambling Task (IGT). We found a moderate to large effect for SUD on both, the IGT and DD. While the effect on the DD was generalized to all substance classes, a smaller effect for cannabis-related disorder when compared to other SUDs was found with regard to the IGT. Early onset of substance use and psychiatric comorbidities were associated with stronger effects on the DD. Our findings suggest that feedback processing is more vulnerable to specific substance effects, while valuation of delayed gratification depends more on developmental and clinical factors.

Keywords: Addiction; Cognition; Decision-making; Impulse control; Impulsivity; Reward impulsivity; Risk-taking; Substance use related disorders; Temporal discounting.

Publication types

Meta-Analysis
Research Support, Non-U.S. Gov't
Review

MeSH terms

Delay Discounting / physiology*
Feedback, Psychological / physiology*
Humans
Reward*
Substance-Related Disorders / physiopathology*