1H-NMR spectroscopy identifies potential biomarkers in serum metabolomic signatures for early stage esophageal squamous cell carcinoma

PeerJ. 2019 Nov 29:7:e8151. doi: 10.7717/peerj.8151. eCollection 2019.

Abstract

Background: Esophageal squamous cell carcinoma (ESCC) is one of the most prevalent types of upper gastrointestinal malignancies. Here, we used 1H nuclear magnetic resonance spectroscopy (1H-NMR) to identify potential serum biomarkers in patients with early stage ESCC.

Methods: Sixty-five serum samples from early stage ESCC patients (n = 25) and healthy controls (n = 40) were analysed using 1H-NMR spectroscopy. We distinguished between different metabolites through principal component analysis, partial least squares-discriminant analysis, and orthogonal partial least squares-discriminant analysis (OPLS-DA) using SIMCA-P+ version 14.0 software. Receiver operating characteristic (ROC) analysis was conducted to verify potential biomarkers.

Results: Using OPLS-DA, 31 altered serum metabolites were successfully identified between the groups. Based on the area under the ROC curve (AUROC), and the biomarker panel with AUROC of 0.969, six serum metabolites (α-glucose, choline, glutamine, glutamate, valine, and dihydrothymine) were selected as potential biomarkers for early stage ESCC. Dihydrothymine particularly was selected as a new feasible biomarker associated with tumor occurrence.

Conclusions: 1H-NMR spectroscopy may be a useful tumour detection approach in identifying useful metabolic ESCC biomarkers for early diagnosis and in the exploration of the molecular pathogenesis of ESCC.

Keywords: 1H- NMR spectroscopy; Biomarker; Esophageal squamous cell carcinoma; Metabolomics.

Grants and funding

This work was supported by the National Natural Science Foundation of China (NO. 81672918), the Guangdong Basic and Applied Basic Research Foundation (NO. 2018A030310154), and the Medical Scientific Research Foundation of Guangdong Province (NO. A2017532). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.