Azidothymidine-induced depression of murine hemopoietic progenitor cells

G Bogliolo; R Lerza; M Mencoboni; A Saviane; I Pannacciulli

Azidothymidine-induced depression of murine hemopoietic progenitor cells

Exp Hematol. 1988 Dec;16(11):938-40.

Authors

G Bogliolo¹, R Lerza, M Mencoboni, A Saviane, I Pannacciulli

Affiliation

¹ Istituto Scientifico di Medicina Interna, University of Genoa, Italy.

PMID: 3181343

Abstract

The toxicity of the antiviral drug 3'-azido-3'-deoxythymidine was studied in vivo on murine hemopoietic progenitor cells and peripheral blood cells. The drug induced a marked decrease of all tested populations, showing a severe toxicity on hemopoiesis.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Blood Cells / drug effects
Bone Marrow Cells
Female
Hematopoietic Stem Cells / drug effects*
Male
Mice
Mice, Inbred DBA
Zidovudine / pharmacology*

Substances

Zidovudine