Impact of Candida auris Infection in a Neutropenic Murine Model

Steven R Torres; Amber Pichowicz; Fernando Torres-Velez; Renjie Song; Navjot Singh; Erica Lasek-Nesselquist; Magdia De Jesus

doi:10.1128/AAC.01625-19

Impact of Candida auris Infection in a Neutropenic Murine Model

Antimicrob Agents Chemother. 2020 Feb 21;64(3):e01625-19. doi: 10.1128/AAC.01625-19. Print 2020 Feb 21.

Authors

Steven R Torres^#^{1

2}, Amber Pichowicz^#³, Fernando Torres-Velez², Renjie Song⁴, Navjot Singh⁵, Erica Lasek-Nesselquist⁶, Magdia De Jesus^{7

2}

Affiliations

¹ Department of Biomedical Sciences, University at Albany, School of Public Health, Albany, New York, USA.
² Division of Infectious Diseases, Wadsworth Center, New York State Department of Health, Albany, New York, USA.
³ College of Nursing and Health Sciences, University of Vermont, Burlington, Vermont, USA.
⁴ Biochemistry and Immunology Core, Wadsworth Center, New York State Department of Health, Albany, New York, USA.
⁵ Applied Genomics Technology Core, Wadsworth Center, New York State Department of Health, Albany, New York, USA.
⁶ Center for Bioinformatics, Wadsworth Center, New York State Department of Health, Albany, New York, USA.
⁷ Department of Biomedical Sciences, University at Albany, School of Public Health, Albany, New York, USA [email protected].

^# Contributed equally.

Abstract

Candida auris has become a global public health threat due to its multidrug resistance and persistence. Currently, there are limited murine models to study C. auris infection. Those models use a combination of cyclophosphamide and cortisone acetate, suppressing both innate and adaptive immunity. Here, we compare C. auris infection in two neutrophil-depleted murine models in which innate immunity is targeted using the monoclonal antibodies 1A8 and RB6-8C5.

Keywords: Candida auris; Ly6C; Ly6G; microbiome; neutrophil depletion; torticollis.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antibodies, Monoclonal
Candida / drug effects
Candida / genetics
Candida / pathogenicity*
Candidiasis / drug therapy*
Candidiasis / immunology
Candidiasis / microbiology
Cortisone / therapeutic use*
Cyclophosphamide / therapeutic use*
Disease Models, Animal
Immunity, Innate / drug effects
Immunity, Innate / physiology
Mice
Neutrophils / metabolism

Substances

Antibodies, Monoclonal
Cyclophosphamide
Cortisone