Impairment of Myocardial Glutamine Homeostasis Induced By Suppression of the Amino Acid Carrier SLC1A5 in Failing Myocardium

Circ Heart Fail. 2019 Dec;12(12):e006336. doi: 10.1161/CIRCHEARTFAILURE.119.006336. Epub 2019 Dec 12.

Authors

Affiliations

¹ Division of Cardiology (P.J.K., X.L., A.S., R.J., X.Z., D.B.).
² Division of Cardiology, Department of Internal Medicine I, University Hospital Jena, Friedrich-Schiller-University, Germany (P.J.K., P.C.S.).
³ Division of Cardiothoracic Surgery, College of Physicians and Surgeons (E.C., H.T., Y.N., I.G.).
⁴ Mount Sinai Heart, New York (D.B., D.M.).
⁵ Department of Pathology and Cell Biology (T.T.), Columbia University, New York, NY.

PMID: 31826641
DOI: 10.1161/CIRCHEARTFAILURE.119.006336

No abstract available

Keywords: glutamine; heart failure; homeostasis; myocardium; phenotype.

Publication types

Letter
Research Support, N.I.H., Extramural

MeSH terms

Amino Acid Transport System ASC / genetics
Amino Acid Transport System ASC / metabolism*
Case-Control Studies
Chronic Disease
Down-Regulation
Glutamine / metabolism*
Heart Failure / diagnosis
Heart Failure / metabolism*
Heart Failure / physiopathology
Heart Failure / therapy
Heart-Assist Devices
Homeostasis
Humans
Minor Histocompatibility Antigens / genetics
Minor Histocompatibility Antigens / metabolism*
Myocardium / metabolism*
Ventricular Function, Left

Substances

Amino Acid Transport System ASC
Minor Histocompatibility Antigens
SLC1A5 protein, human
Glutamine

Grants and funding

R01 HL114813/HL/NHLBI NIH HHS/United States