Symmetric dimethylation of poly-GR correlates with disease duration in C9orf72 FTLD and ALS and reduces poly-GR phase separation and toxicity

Acta Neuropathol. 2020 Feb;139(2):407-410. doi: 10.1007/s00401-019-02104-x. Epub 2019 Dec 12.

Lauren M Gittings^{1

2

3}, Steven Boeynaems⁴, Daniel Lightwood⁵, Alison Clargo⁵, Sarfaraj Topia⁵, Lisa Nakayama⁴, Claire Troakes⁶, David M A Mann⁷, Aaron D Gitler⁴, Tammaryn Lashley^{1

3}, Adrian M Isaacs^{8

9}

¹ Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, WC1N 3BG, UK.
² UK Dementia Research Institute at UCL, Cruciform Building, Gower Street, London, WC1E 6BT, UK.
³ Queen Square Brain Bank for Neurological Disorders, UCL Queen Square Institute of Neurology, London, UK.
⁴ Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.
⁵ UCB Pharma, 216 Bath Road, Slough, SL1 3WE, UK.
⁶ London Neurodegenerative Diseases Brain Bank, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
⁷ Division of Neuroscience and Experimental Psychology, School of Biological Sciences, University of Manchester, Salford Royal Hospital, Salford, UK.
⁸ Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, WC1N 3BG, UK. [email protected].
⁹ UK Dementia Research Institute at UCL, Cruciform Building, Gower Street, London, WC1E 6BT, UK. [email protected].

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