Abstract
Background:
This report summarizes the discussions and conclusions from the "Immunological Assays and Correlates of Protection for Next-Generation Influenza Vaccines" meeting which took place in Siena, Italy, from March 31, 2019, to April 2, 2019.
Conclusions:
Furthermore, we review current correlates of protection against influenza virus infection and disease and their usefulness for the development of next generation broadly protective and universal influenza virus vaccines.
Keywords:
CD4; CD8; HI; MN; NI; correlates of protection; influenza; influenza vaccine; mucosal immunity; stalk antibodies.
Published 2019. This article is a U.S. Government work and is in the public domain in the USA. Influenza and Other Respiratory Viruses published by John Wiley & Sons Ltd.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Antibodies, Neutralizing / blood
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Antibodies, Viral / blood
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CD4-Positive T-Lymphocytes / immunology
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CD8-Positive T-Lymphocytes / immunology
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Hemagglutination Inhibition Tests
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Hemagglutinin Glycoproteins, Influenza Virus / immunology
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Humans
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Immunity, Mucosal
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Influenza A Virus, H1N1 Subtype / immunology
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Influenza Vaccines / biosynthesis
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Influenza Vaccines / immunology*
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Influenza, Human / immunology*
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Influenza, Human / prevention & control
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Models, Animal
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Neuraminidase / blood
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Neuraminidase / immunology
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Orthomyxoviridae Infections / immunology
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Orthomyxoviridae Infections / prevention & control
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Serologic Tests / methods
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Vaccination
Substances
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Antibodies, Neutralizing
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Antibodies, Viral
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Hemagglutinin Glycoproteins, Influenza Virus
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Influenza Vaccines
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Neuraminidase