Use of miltefosine in a patient with mucosal leishmaniasis and HIV-coinfection: a challenge in long-term management

Giacomo Zanelli; Barbara Rossetti; Roberta Gagliardini; Lorenzo Paglicci; Giacinta Tordini; Clelia Miracco; Sara Aversa; Lorenzo Zammarchi; Trentina Di Muccio; Marina Gramiccia; Francesca Montagnani

Use of miltefosine in a patient with mucosal leishmaniasis and HIV-coinfection: a challenge in long-term management

Infez Med. 2019 Dec 1;27(4):452-455.

Affiliations

¹ Hospital Department of Specialized and Internal Medicine, Infectious Diseases Unit, University Hospital of Siena, Siena, Italy; Department of Medical Biotechnologies, University of Siena, Italy.
² Hospital Department of Specialized and Internal Medicine, Infectious Diseases Unit, University Hospital of Siena, Siena, Italy.
³ Hospital Department of Specialized and Internal Medicine, Infectious Diseases Unit, University Hospital of Siena, Siena, Italy; INMI L.Spallanzani IRCCS, Rome, Italy.
⁴ Hospital Department of Specialized and Internal Medicine, Infectious Diseases Unit, University Hospital of Siena, Siena, Italy; Department of Medical Biotechnologies, University of Siena, Italy 3INMI L.Spallanzani IRCCS, Rome, Italy.
⁵ Pathological Anatomy Division, Department of Medicine, Surgery and Neuroscience, University of Siena, Siena, Italy.
⁶ Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy; Infectious and Tropical Diseases Unit, Careggi University and Hospital, Florence, Italy; Referral Center for Tropical Diseases of Tuscany, Infectious and Tropical Diseases Unit, Careggi University Hospital, Florence, Italy.
⁷ Department of Infectious Diseases, Unit of Vector-borne Diseases, Italian National Institute of Health, Rome, Italy.

PMID: 31846999

Abstract

The management of mucosal leishmaniasis in immunocompromised patients is not standardized and limited data are available on the use of miltefosine for treatment and secondary prophylaxis. We describe a case of mucosal leishmaniasis in an HIV-coinfected patient treated with miltefosine due to a severe allergic reaction to liposomal amphotericin B.

Publication types

Case Reports

MeSH terms

Coinfection
HIV Infections / complications
Humans
Leishmaniasis, Mucocutaneous / complications
Leishmaniasis, Mucocutaneous / drug therapy*
Male
Middle Aged
Phosphorylcholine / analogs & derivatives*
Phosphorylcholine / therapeutic use
Time Factors

Substances

Phosphorylcholine
miltefosine