Probiotics, including nisin-based probiotics, improve clinical and microbial outcomes relevant to oral and systemic diseases

Trang Nguyen; Hanna Brody; Guo-Hao Lin; Hélène Rangé; Ryutaro Kuraji; Changchang Ye; Pachiyappan Kamarajan; Allan Radaic; Li Gao; Yvonne Kapila

doi:10.1111/prd.12324

Probiotics, including nisin-based probiotics, improve clinical and microbial outcomes relevant to oral and systemic diseases

Periodontol 2000. 2020 Feb;82(1):173-185. doi: 10.1111/prd.12324.

Authors

Trang Nguyen¹, Hanna Brody¹, Guo-Hao Lin², Hélène Rangé^{2

3

4}, Ryutaro Kuraji^{2

5

6}, Changchang Ye^{2

7}, Pachiyappan Kamarajan², Allan Radaic^{2

8}, Li Gao^{2

9}, Yvonne Kapila²

Affiliations

¹ School of Dentistry, University of California San Francisco, San Francisco, California, USA.
² Department of Orofacial Sciences, School of Dentistry, University of California San Francisco, San Francisco, California, USA.
³ Department of Periodontology, UFR of Odontology, APHP, Rothschild Hospital, University of Paris Diderot, Paris, France.
⁴ Faculty of Dental Surgery, University of Paris Descartes, Montrouge, France.
⁵ Department of Life Science Dentistry, The Nippon Dental University, Tokyo, Japan.
⁶ Department of Periodontology, The Nippon Dental University School of Life Dentistry at Tokyo, Tokyo, Japan.
⁷ State Key Laboratory of Oral Diseases, Department of Periodontology, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
⁸ Laboratory of Neuroproteomics, Department of Biochemistry and Tissue Biology, Institute of Biology, The University of Campinas, Campinas, Sao Paulo, Brazil.
⁹ Department of Periodontology, Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University, Guangzhou, China.

PMID: 31850634
DOI: 10.1111/prd.12324

Abstract

The effects of probiotic supplementation on systemic health and gastrointestinal diseases have been investigated in numerous studies. The aim of this review is to provide an overview of probiotics and their effects on periodontal health. Probiotics show beneficial effects as adjunctive therapeutics and as stand-alone agents in the treatment and prevention of gingivitis as well as specific clinical parameters of periodontitis. This review focuses on the clinical and microbiological aspects of probiotics in the context of health, gingivitis, and periodontitis. In addition, a special focus on nisin-producing probiotics and nisin itself showcase their significant potential for oral and systemic use.

Keywords: clinical efficacy; nisin; oral microbiome; periodontal diseases; probiotics.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Gingivitis*
Humans
Nisin*
Periodontitis*
Probiotics*

Substances

Nisin