Objective: To explore the clinical characteristics, treatment strategy and prognosis of adenoid cystic carcinoma of the head and neck (ACCHN). Methods: A retrospective analysis of the clinical and follow-up treatment of 79 patients with ACCHN from June 2008 to July 2017 was conducted in the Cancer Hospital of Zhengzhou University. Results: A total of 79 ACCHN cases, including 31 males and 48 females. The age ranged from 19 to 77 (median, 52). The clinical manifestations of ACC were related to the locations of primary tumor.The mean size of the tumor was 2.6 cm (range from 1.5 to 7.7 cm). 50 of 79 patients with a definitive pathological diagnosis received surgical resection. 59 cases received chemotherapy and 62 cases received radiotherapy. With a median follow-up of 55 months, the 5-year, 10-year survival rate of these patients were 69.6% and 54.4%, respectively. Conclusions: ACCHN is an uncommon neoplasm with the characteristics of epithelial nerve growth, being inclined to distant metastasis, and high early misdiagnosis rate. The clinical manifestation, imaging and pathological result are need to be combined together to diagnose ACCHN.
目的： 探讨头颈部腺样囊性癌(ACC)的临床特征、治疗策略和预后。 方法： 回顾性分析郑州大学附属肿瘤医院2008年6月至2017年7月间收治的79例头颈部ACC患者的临床和随访资料。 结果： 79例头颈部ACC患者中，男性31例，女性48例；年龄19～77岁，中位年龄52岁。大涎腺来源29例(其中颌下腺14例，腮腺12例，舌下腺3例)，小涎腺来源48例(其中鼻腔鼻窦25例，口腔21例，口咽2例)，外耳道1例，眼眶1例。多为肿物、疼痛、鼻塞、流涕、头痛等症状。头颈部ACC的临床表现与肿瘤的生长部位有关。肿瘤直径1.5～7.7 cm，平均直径2.6 cm。79例患者中，有50例患者行手术治疗，术后病理检查均证实为ACC。59例行化疗，62例行放疗。全组患者的中位随访时间为55个月，5年和10年生存率分别为69.6%和54.4%。 结论： 头颈部ACC是较少见的恶性肿瘤，临床表现和肿瘤生长部位有关，具有噬神经生长、易远处转移、早期误诊率高等特点，诊断需结合临床、影像学检查和病理结果。.
Keywords: Adenoid cystic carcinoma, head and neck; Clinical characteristics; Prognosis; Treatment.