Expression and prognostic analyses of ITGA11, ITGB4 and ITGB8 in human non-small cell lung cancer

Pancheng Wu; Yanyu Wang; Yijun Wu; Ziqi Jia; Yang Song; Naixin Liang

doi:10.7717/peerj.8299

Expression and prognostic analyses of ITGA11, ITGB4 and ITGB8 in human non-small cell lung cancer

PeerJ. 2019 Dec 20:7:e8299. doi: 10.7717/peerj.8299. eCollection 2019.

Authors

Pancheng Wu^#¹, Yanyu Wang^#¹, Yijun Wu², Ziqi Jia², Yang Song³, Naixin Liang³

Affiliations

¹ Department of Thoracic Surgery, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China.
² Peking Union Medical College, Eight-Year MD Program, Chinese Academy of Medical Sciences, Beijing, China.
³ Department of Thoracic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China.

^# Contributed equally.

Abstract

Background: Integrins play a crucial role in the regulation process of cell proliferation, migration, differentiation, tumor invasion and metastasis. ITGA11, ITGB4 and ITGB8 are three encoding genes of integrins family. Accumulative evidences have proved that abnormal expression of ITGA11, ITGB4 and ITGB8 are a common phenomenon in different malignances. However, their expression patterns and prognostic roles for patients with non-small cell lung cancer (NSCLC) have not been completely illustrated.

Methods: We investigated the expression patterns and prognostic values of ITGA11, ITGB4 and ITGB8 in patients with NSCLC through using a series of databases and various datasets, including ONCOMINE, GEPIA, HPA, TCGA and GEO datasets.

Results: We found that the expression levels of ITGA11 and ITGB4 were significantly upregulated in both LUAD and LUSC, while ITGB8 was obviously upregulated in LUSC. Additionally, higher expression level of ITGB4 revealed a worse OS in LUAD.

Conclusion: Our findings suggested that ITGA11 and ITGB4 might have the potential ability to act as diagnostic biomarkers for both LUAD and LUSC, while ITGB8 might serve as diagnostic biomarker for LUSC. Furthermore, ITGB4 could serve as a potential prognostic biomarker for LUAD.

Keywords: Expression and prognostic analysis; ITGA11; ITGB4; ITGB8; Non-small cell lung cancer.

Grants and funding

This work was supported by the Natural Science Foundation of Beijing, China (Grant No. 7182132). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.