68Ga-PMSA Uptake in the Lung: Metastatic Versus Primary Lung Tumor

Clin Nucl Med. 2020 Feb;45(2):e80-e82. doi: 10.1097/RLU.0000000000002870.

Abstract

Ga-PSMA is a promising tracer for both primary staging and detection of biochemical recurrence in prostate cancer. PSMA is also expressed in the neovascular endothelium of various solid malignancies possibly due to tumor-associated angiogenic factors and endothelial cell sprouting. We report a case of a 73-year-old man of prostate cancer with rising prostate-specific antigen levels. Ga-PSMA PET/CT was performed, which showed a focal lung lesion, with subsequent histological confirmation of adenocarcinoma of the lung. Incidental lung lesions on Ga-PSMA in prostate cancer patients should elicit a differential of primary lung malignancy, especially if clinical and morphological suspicion is high.

Publication types

  • Case Reports
  • Comparative Study

MeSH terms

  • Aged
  • Biological Transport
  • Gallium Isotopes
  • Gallium Radioisotopes
  • Humans
  • Lung Neoplasms / diagnostic imaging
  • Lung Neoplasms / metabolism*
  • Lung Neoplasms / secondary*
  • Male
  • Membrane Glycoproteins / metabolism*
  • Neoplasm Metastasis
  • Organometallic Compounds / metabolism*
  • Positron Emission Tomography Computed Tomography
  • Prostatic Neoplasms / pathology

Substances

  • Gallium Isotopes
  • Gallium Radioisotopes
  • Membrane Glycoproteins
  • Organometallic Compounds
  • gallium 68 PSMA-11