Neuroprotective effect of metformin on dopaminergic neurodegeneration and α-synuclein aggregation in C. elegans model of Parkinson's disease

Neurosci Res. 2021 Jan:162:13-21. doi: 10.1016/j.neures.2019.12.017. Epub 2019 Dec 24.

Authors

Nada Saewanee¹, Theethawat Praputpittaya¹, Nawaphat Malaiwong², Pawanrat Chalorak², Krai Meemon³

Affiliations

¹ Mahidol University International College, 999 Phutthamonthon 4 Road, Salaya, Nakhon Pathom, 73170, Thailand.
² Department of Anatomy, Faculty of Science, Mahidol University, Rama VI Road, Bangkok, 10400, Thailand.
³ Department of Anatomy, Faculty of Science, Mahidol University, Rama VI Road, Bangkok, 10400, Thailand. Electronic address: [email protected].

PMID: 31881233
DOI: 10.1016/j.neures.2019.12.017

No abstract available

Keywords: Caenorhabditis elegans; Dopaminergic neuron; Metformin; Neuroprotection; Parkinson’s Disease; α-Synuclein.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Animals, Genetically Modified
Caenorhabditis elegans
Caenorhabditis elegans Proteins* / genetics
Disease Models, Animal
Dopaminergic Neurons
Metformin* / pharmacology
Neuroprotective Agents* / pharmacology
Parkinson Disease* / drug therapy
alpha-Synuclein

Substances

Caenorhabditis elegans Proteins
Neuroprotective Agents
alpha-Synuclein
Metformin

Grants and funding

P40 OD010440/OD/NIH HHS/United States