Persistence of antibody titres three years after vaccination with Vi polysaccharide vaccine against typhoid fever

C O Tacket; M M Levine; J B Robbins

doi:10.1016/0264-410x(88)90175-2

Persistence of antibody titres three years after vaccination with Vi polysaccharide vaccine against typhoid fever

Vaccine. 1988 Aug;6(4):307-8. doi: 10.1016/0264-410x(88)90175-2.

Authors

C O Tacket¹, M M Levine, J B Robbins

Affiliation

¹ Department of Medicine, University of Maryland, Baltimore 21201.

PMID: 3188615
DOI: 10.1016/0264-410x(88)90175-2

Abstract

After a single injection of purified Vi polysaccharide vaccine against typhoid fever, serum titres were followed in student volunteers by passive haemagglutination assay and by radioimmunoassay. Elevated Vi antibody titres were still present after 36 months. This preliminary study should be followed by further investigations on the extent and duration of protection provided by Vi vaccine, and on volunteers in endemic areas.

MeSH terms

Adult
Antibodies, Bacterial / analysis*
Antigens, Bacterial / immunology*
Hemagglutination Tests
Humans
Polysaccharides, Bacterial / immunology*
Radioimmunoassay
Salmonella typhi / immunology*
Time Factors
Typhoid Fever / prevention & control
Typhoid-Paratyphoid Vaccines / immunology*
Vaccination

Substances

Antibodies, Bacterial
Antigens, Bacterial
Polysaccharides, Bacterial
Typhoid-Paratyphoid Vaccines
Vi polysaccharide vaccine, typhoid