BET inhibition prevents aberrant RUNX1 and ERG transcription in STAG2 mutant leukaemia cells

J Mol Cell Biol. 2020 Jun 11;12(5):397-399. doi: 10.1093/jmcb/mjz114.

Jisha Antony^{1

2}, Gregory Gimenez¹, Terry Taylor³, Umaima Khatoon¹, Robert Day⁴, Ian M Morison¹, Julia A Horsfield^{1

2}

¹ Department of Pathology, Dunedin School of Medicine, University of Otago, Dunedin 9016, New Zealand.
² Maurice Wilkins Centre for Molecular Biodiscovery, The University of Auckland, Private Bag 92019, Auckland, New Zealand.
³ Southern Community Laboratories, Dunedin 9016, New Zealand.
⁴ Department of Biochemistry, University of Otago, Dunedin 9054, New Zealand.

No abstract available

Keywords: CRISPR-Cas9; ERG; RUNX1; STAG2; chromatin; cohesin; enhancer; inducible; megakaryocyte.

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