Immunological role and underlying mechanisms of B7-H6 in tumorigenesis

Yuxuan Hu; Tian Zeng; Zheng Xiao; Qihao Hu; Yukun Li; Xiongjin Tan; Haiyan Yue; Wensong Wang; Hui Tan; Juan Zou

doi:10.1016/j.cca.2019.12.030

Immunological role and underlying mechanisms of B7-H6 in tumorigenesis

Clin Chim Acta. 2020 Mar:502:191-198. doi: 10.1016/j.cca.2019.12.030. Epub 2020 Jan 3.

Authors

Yuxuan Hu¹, Tian Zeng¹, Zheng Xiao¹, Qihao Hu², Yukun Li¹, Xiongjin Tan³, Haiyan Yue⁴, Wensong Wang¹, Hui Tan⁵, Juan Zou⁶

Affiliations

¹ Hunan Province Key Laboratory of Tumor Cellular & Molecular Pathology, Cancer Research Institute, University of South China, Hengyang, Hunan 421001, PR China.
² Cardiothoracic Surgery, The Second Affiliated Hospital, University of South China, Hengyang, Hunan 421001, PR China.
³ The Second Department of Orthopaedic, 922 Hospital of PLA, Hengyang, Hunan 410011, PR China.
⁴ Hunan Province Key Laboratory of Tumor Cellular & Molecular Pathology, Cancer Research Institute, University of South China, Hengyang, Hunan 421001, PR China; Department of Pathology, The Central Hospital of Shaoyang, Shaoyang, Hunan 422000, PR China.
⁵ Hunan Province Key Laboratory of Tumor Cellular & Molecular Pathology, Cancer Research Institute, University of South China, Hengyang, Hunan 421001, PR China. Electronic address: [email protected].
⁶ Hunan Province Key Laboratory of Tumor Cellular & Molecular Pathology, Cancer Research Institute, University of South China, Hengyang, Hunan 421001, PR China. Electronic address: [email protected].

PMID: 31904350
DOI: 10.1016/j.cca.2019.12.030

Abstract

B7 homolog 6 (B7-H6) has been identified as involved in tumorigenesis. Elucidating its role and potential mechanism of action is essential for understanding tumorigenesis and the potential development of an effective clinical strategy. Abnormal overexpression of B7-H6 in various types of tumors was reported to be linked with poor prognosis. B7-H6 suppresses the initiation of the "caspase cascade" and induces anti-apoptosis by STAT3 pathway activation to provoke tumorigenesis. B7-H6 facilitates tumor proliferation and cell cycle progression by regulating apoptosis suppressors. B7-H6 induces cellular cytotoxicity, secretion of TNF-α and IFN-γ and B7-H6-specific BiTE triggers T cells to accelerate tumorigenesis. B7-H6 induces abnormal immunological progression by HER2-scFv mediated ADCC and NKp30 immune escape to promote tumorigenesis. B7-H6 promotes tumorigenesis via apoptosis inhibition, proliferation and immunological progression. B7-H6 may a valuable potential biomarker and therapeutic strategy for diagnostics, prognostics and treatment in cancer.

Keywords: Apoptotic; B7-H6; Immunological progression; Proliferation; Tumorigenesis.

Publication types

Review

MeSH terms

B7 Antigens / immunology*
Humans
Neoplasms / immunology*
Neoplasms / pathology

Substances

B7 Antigens
NCR3LG1 protein, human