A retrospective study of antibodies against basement membrane antigens (type IV collagen and laminin) in patients with primary and secondary Raynaud's phenomenon

Arthritis Rheum. 1988 Nov;31(11):1432-6. doi: 10.1002/art.1780311114.

Abstract

Antibodies against type IV collagen were detected in the sera of 21% of patients with primary Raynaud's phenomenon (PRP) and 68% of patients with systemic sclerosis. Sera from 25% of the PRP patients and 48% of systemic sclerosis patients displayed antibodies to laminin. Eighty percent of the patients with PRP and antibodies to basement membrane antigens developed additional serologic or clinical manifestations, whereas only 16% of patients with PRP and no anti-basement membrane antibodies developed such manifestations.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Antibodies / analysis
  • Antibodies / immunology*
  • Basement Membrane / immunology*
  • Collagen / classification
  • Collagen / immunology*
  • Connective Tissue Diseases / complications
  • Connective Tissue Diseases / immunology
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Humans
  • Laminin / immunology*
  • Male
  • Middle Aged
  • Raynaud Disease / complications
  • Raynaud Disease / immunology*
  • Reference Values
  • Retrospective Studies

Substances

  • Antibodies
  • Laminin
  • Collagen