Adjustment of Subthalamic Deep Brain Stimulation Parameters Improves Wheeze and Dyspnea in Parkinson's Disease

Hiroyasu Komiya; Katsuo Kimura; Hitaru Kishida; Takashi Kawasaki; Koichi Hamada; Hiroyuki Koizumi; Naohisa Ueda; Fumiaki Tanaka

doi:10.3389/fneur.2019.01317

Adjustment of Subthalamic Deep Brain Stimulation Parameters Improves Wheeze and Dyspnea in Parkinson's Disease

Front Neurol. 2019 Dec 13:10:1317. doi: 10.3389/fneur.2019.01317. eCollection 2019.

Authors

Hiroyasu Komiya¹, Katsuo Kimura¹, Hitaru Kishida¹, Takashi Kawasaki², Koichi Hamada², Hiroyuki Koizumi¹, Naohisa Ueda¹, Fumiaki Tanaka³

Affiliations

¹ Department of Neurology, Yokohama City University Medical Center, Yokohama, Japan.
² Department of Neurosurgery, Yokohama City University Medical Center, Yokohama, Japan.
³ Department of Neurology and Stroke Medicine, Yokohama City University Graduate School of Medicine, Yokohama, Japan.

Abstract

Subthalamic nucleus deep brain stimulation (STN-DBS) is an effective treatment for motor features in Parkinson's disease (PD). We present the case of a 56-year-old man with a 17-year history of PD. He underwent bilateral STN-DBS at the age of 51 years because of troublesome dyskinesia and wearing off. His motor features dramatically improved after the operation; however, he developed dysarthria and a refractory wheeze associated with dyspnea due to abnormal hyperadduction of the false vocal fold. By adjusting the stimulation site of STN, his severe wheeze, which was considered to be the result of the unfavorable spread of current to the corticobulbar tract, was significantly improved. This report provides concrete evidence that wheezing is caused by hyperadduction of the false vocal fold as an adverse effect of STN-DBS and can be reversed by adjusting the stimulation site for STN-DBS.

Keywords: Parkinson's disease; deep brain stimulation; hyperadduction of the false vocal fold; laryngeal dystonia; wheeze.

Publication types

Case Reports