Management of civilians with penetrating brain injury: A systematic review

J Crit Care. 2020 Apr:56:159-166. doi: 10.1016/j.jcrc.2019.12.026. Epub 2020 Jan 2.

Abstract

Purpose: There has been a dramatic increase in penetrating gunshot-inflicted civilian penetrating brain injuries (cvPBI). We undertook a systematic review with exclusive focus on the management of cvPBI.

Methods: We explored: (1) cervical spine immobilization, (2) seizure incidence and prophylaxis, (3) infection incidence and antibiotic prophylaxis, (4) coagulopathy (5) vascular complications, and (6) surgical management. We searched PubMed, EMBASE, and Cochrane (1985-2019). The PRISMA guidelines were followed. The Newcastle-Ottawa Scale was employed for qualitative assessment; risk of bias was evaluated based upon the RTI item bank. The full protocol was registered to PROSPERO (CRD42019118877).

Results: The literature is scant, and of overall low quality and high risk of bias. Incidence of c-spine injury with no direct trauma is low; incidence of seizures does not appear to be different from non-penetrating mechanisms; there is no robust data for prophylactic antibiotics; coagulopathy is prevalent and has been independently associated with outcome; there is a high incidence of vascular injuries with traumatic intracranial aneurysms the most common sequelae; neurosurgical decision-making appears largely influenced by operator's assessment of salvageability. Surgery has been associated with decreased mortality.

Conclusions: Limited amount of published work is clinically meaningful; this systematic review identified key knowledge gaps.

Keywords: Civilian gunshot wound to the head; Civilian penetrating brain injury; Civilian traumatic brain injury; GSWH; cvPBI.

Publication types

  • Systematic Review

MeSH terms

  • Antibiotic Prophylaxis
  • Craniocerebral Trauma / etiology
  • Craniocerebral Trauma / surgery
  • Head Injuries, Penetrating / complications
  • Head Injuries, Penetrating / surgery*
  • Hematologic Diseases / complications
  • Humans
  • Incidence
  • Intracranial Aneurysm
  • Neurosurgical Procedures
  • Risk Assessment
  • Seizures / prevention & control*
  • Spinal Injuries / complications
  • Treatment Outcome
  • Vascular Diseases / complications
  • Wounds, Gunshot*