Abstract
Detection of Aβ protofibrils at the early stage of Alzheimer's disease was realized by a novel near-infrared probe (DCM-AN) based on dicyanomethylene-4H-pyran. This probe exhibits high affinity towards Aβ protofibrils in vitro and in brain sections of transgenic mouse models for Alzheimer's disease.
MeSH terms
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2-Naphthylamine / analogs & derivatives
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2-Naphthylamine / chemical synthesis
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2-Naphthylamine / toxicity
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Alzheimer Disease / metabolism*
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Alzheimer Disease / pathology
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Amyloid beta-Peptides / analysis*
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Animals
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Brain / metabolism
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Brain / pathology
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Female
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Fluorescent Dyes / chemistry*
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Fluorescent Dyes / toxicity
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Limit of Detection
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Male
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Mice, Inbred C57BL
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Mice, Transgenic
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Molecular Docking Simulation
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Molecular Dynamics Simulation
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Nitriles / chemical synthesis
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Nitriles / chemistry
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Nitriles / toxicity
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Spectrometry, Fluorescence / methods
Substances
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Amyloid beta-Peptides
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Fluorescent Dyes
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Nitriles
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2-Naphthylamine