Objective: To analyse the outcomes and the prognostic factors of patients with sinonasal malignancies following endoscopic endonasal approach, and to compare the pre- and post-operative quality of life. Methods: A retrospective single-center review of 79 patients who underwent endoscopic endonasal approach for sinonasal malignancies in Beijing Tongren Hospital from October 2004 to March 2017 was performed, including 51 males and 28 females, with a median age of 48 years. Data of demography, imaging (including nasal CT and MRI before operation), histopathology and treatment strategy were collected. Recurrence and distant metastasis were diagnosed according to endoscopic examination, MRI and general check-up after surgery. Pre- and post-operative quality of life scores were obtained by sinonasal outcome test-22, visual analog scale and anterior skull base surgery questionnaire. SPSS 22 software was used for statistical analysis. Results: The study consisted of 13 pathological types with sinonasal T1-T4 stage tumors, including cervical lymph nodes and/or distant metastasis. All patients underwent endoscopic endonasal approach surgery. After 43 months of median follow-up time, the overall, disease-free, and recurrence-free survival rates at 1, 3, 5 and 10 years was 97.4%, 92.5%, 92.5% and 83.7%; 83.2%, 68.3%, 56.8% and 33.6%; 84.5%, 66.6%, 58.0% and 34.4%, respectively. Postoperative recurrence was an independent risk factor affecting the overall survival rate (HR=8.852, P=0.044), and preoperative recurrence (secondary surgery) was an independent risk factor affecting the disease-free and recurrence-free survival rate (HR value was 2.237 and 2.095 respectively, P value was 0.029 and 0.047 respectively). After surgery, the olfaction and nasal scab got worse, while the nasal obstruction and breathing were improved. Conclusions: Endoscopic endonasal approach for sinonasal malignancies can achieve satisfactory outcomes, and has obvious advantages in improving the quality of life. Postoperative recurrence and preoperative recurrence are the prognostic factors.
目的： 分析鼻腔鼻窦恶性肿瘤经鼻内镜手术的疗效及预后因素，比较患者手术前后生活质量变化。 方法： 本研究为单中心回顾性研究，对2004年10月至2017年3月北京同仁医院收治的经鼻内镜手术的鼻腔鼻窦恶性肿瘤病例79例进行分析，男性51例，女性28例，中位发病年龄48岁。收集患者人口学资料、术前鼻窦CT、MRI、组织病理学检查结果及治疗方案；依据术后鼻内镜检查、鼻窦MRI及全身检查判定患者是否出现复发和远处转移。通过鼻腔鼻窦结局测试22、视觉模拟量表和前颅底手术问卷调查获得患者手术前后生活质量评分。应用SPSS 22软件进行统计学分析。 结果： 本研究包含13种病理类型的鼻腔鼻窦T1~T4期肿瘤，存在颈部淋巴结及远处转移情况。所有患者均经鼻内镜手术治疗，经过43个月中位随访时间，1、3、5、10年总体生存率、无瘤生存率和无复发生存率分别为97.4%、92.5%、92.5%和83.7%；83.2%、68.3%、56.8%和33.6%；84.5%、66.6%、58.0%和34.4%。术后复发是影响总体生存率下降的独立危险因素（HR=8.852，P=0.044），术前复发（即二次手术）是影响无瘤生存率和无复发生存率下降的独立危险因素（HR值分别为2.237、2.095，P值分别为0.029、0.047）。术后患者出现嗅觉减退、鼻内干痂增多，但鼻塞和呼吸费力等多项表现均有改善。 结论： 经鼻内镜手术治疗鼻腔鼻窦恶性肿瘤可带来令人满意的疗效，在改善生活质量方面有明显优势，术后复发和术前复发是影响预后的因素。.
Keywords: Nasal endoscopic surgery; Nose neoplasms; Prognosis; Quality of life; Treatment outcome.