MDA5+ Dermatomyositis Is Associated with Stronger Skin Type I Interferon Transcriptomic Signature with Upregulation of IFN-κ Transcript

J Invest Dermatol. 2020 Jun;140(6):1276-1279.e7. doi: 10.1016/j.jid.2019.10.020. Epub 2020 Jan 16.
No abstract available

Publication types

  • Letter
  • Observational Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Autoantibodies / immunology
  • Autoantibodies / isolation & purification
  • Case-Control Studies
  • Dermatomyositis / genetics
  • Dermatomyositis / immunology*
  • Dermatomyositis / pathology
  • Female
  • Gene Expression Profiling
  • Gene Expression Regulation / immunology*
  • Humans
  • Interferon Type I / genetics*
  • Interferon-Induced Helicase, IFIH1 / immunology*
  • Male
  • Middle Aged
  • Oligonucleotide Array Sequence Analysis
  • Skin / immunology
  • Skin / pathology
  • Transcriptome / immunology
  • Up-Regulation
  • Young Adult

Substances

  • Autoantibodies
  • Interferon Type I
  • interferon kappa
  • IFIH1 protein, human
  • Interferon-Induced Helicase, IFIH1