Mutations in the hemagglutinin gene associated with influenza virus resistance to norakin

Arch Virol. 1988;102(1-2):125-9. doi: 10.1007/BF01315569.

Abstract

The nucleotide sequences of the hemagglutinin genes of four norakin-resistant mutants of Influenza A/FPV/Weybridge were determined and compared to the wild-type hemagglutinin. All mutants show one or two amino acid substitutions which are discussed to destabilise the pH 7 conformation of hemagglutinin.

MeSH terms

  • Amino Acid Sequence
  • Drug Resistance, Microbial
  • Genes, Viral
  • Hemagglutinins, Viral / genetics*
  • Influenza A virus / drug effects
  • Influenza A virus / genetics*
  • Piperidines / pharmacology*
  • Structure-Activity Relationship

Substances

  • Hemagglutinins, Viral
  • Piperidines
  • triperiden