Optimized fluorodendrimer-incorporated hybrid lipid-polymer nanoparticles for efficient siRNA delivery

Biomater Sci. 2020 Feb 7;8(3):758-762. doi: 10.1039/c9bm01738k. Epub 2020 Jan 22.

Abstract

Six cationic lipidoid fluorodendrimers are synthesized to construct hybrid lipid-polymer nanoparticles for siRNA delivery. By screening the nanoplatforms including fluorodendrimers with different chemical structures, the optimized nanoparticle NPF13-5 mediates the most efficient silencing of prohibitin 1, inhibition of cell proliferation, and induction of cell apoptosis towards A549 lung adenocarcinoma cells.

Publication types

  • Evaluation Study

MeSH terms

  • Cell Line, Tumor
  • Dendrimers / chemistry*
  • Drug Delivery Systems / instrumentation
  • Drug Delivery Systems / methods*
  • Humans
  • Lipids / chemistry*
  • Nanoparticles / chemistry*
  • Polymers / chemical synthesis
  • Polymers / chemistry
  • Prohibitins
  • RNA, Small Interfering / chemistry*
  • RNA, Small Interfering / genetics*
  • Repressor Proteins / genetics

Substances

  • Dendrimers
  • Lipids
  • Polymers
  • Prohibitins
  • RNA, Small Interfering
  • Repressor Proteins