Abstract
Six cationic lipidoid fluorodendrimers are synthesized to construct hybrid lipid-polymer nanoparticles for siRNA delivery. By screening the nanoplatforms including fluorodendrimers with different chemical structures, the optimized nanoparticle NPF13-5 mediates the most efficient silencing of prohibitin 1, inhibition of cell proliferation, and induction of cell apoptosis towards A549 lung adenocarcinoma cells.
MeSH terms
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Cell Line, Tumor
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Dendrimers / chemistry*
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Drug Delivery Systems / instrumentation
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Drug Delivery Systems / methods*
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Humans
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Lipids / chemistry*
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Nanoparticles / chemistry*
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Polymers / chemical synthesis
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Polymers / chemistry
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Prohibitins
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RNA, Small Interfering / chemistry*
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RNA, Small Interfering / genetics*
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Repressor Proteins / genetics
Substances
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Dendrimers
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Lipids
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Polymers
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Prohibitins
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RNA, Small Interfering
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Repressor Proteins