Spinal lesion as the first manifestation of high-grade B-cell lymphoma, with MYC and BCL2 rearrangements

High-grade B-cell lymphoma with MYC and BCL2 rearrangements is a rare lymphoma which has highly aggressive clinical manifestations. The reporting case is a 72-year-old female presented with lumbago and weakness in the lower limb due to a mass at T8-10 revealed by computed tomography (CT) scan. Histological feature of the lesion shows an abundant and diffuse large lymphoid cells infiltration. Immunophenotype meets with germ center B cell (GCB) lymphoma (Hans algorithm). C-MYC and BCL2 gene rearrangements are detected by fluorescence in situ hybridization (FISH). It's a rare and typical case of high-grade B-cell lymphoma with MYC and BCL2 rearrangements with uncommon clinical manifestation.