Neuronal GDPGP1 and glycogen metabolism: friend or foe?

J Cell Biol. 2020 Feb 3;219(2):e202001006. doi: 10.1083/jcb.202001006.

Abstract

The adult brain consumes glucose for energy needs and stores glucose as glycogen mainly in astrocytes. Schulz et al. (2020. J. Cell Biol.https://doi.org/10.1083/jcb.201807127) identify the stress-regulated metabolic enzyme GDPGP1 that promotes neuronal survival likely through glycogen reserves in mouse and C. elegans neurons.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Animals
  • Astrocytes
  • Brain
  • Caenorhabditis elegans*
  • Glycogen
  • Mice
  • Neurons*

Substances

  • Glycogen