Radiotherapy in the Management of Metastatic Hormone-Sensitive Prostate Cancer: What Is the Standard of Care?

Cancer J. 2020 Jan/Feb;26(1):87-93. doi: 10.1097/PPO.0000000000000429.

Abstract

Systemic therapy has historically been the backbone of treatment for patients with metastatic disease. However, recent evidence suggests metastasis-directed therapy in those with oligometastatic disease (≤5 lesions) may improve progression-free and overall survival. Within prostate cancer-specific cohorts, metastasis-directed therapy also appears to delay the time to initiation of androgen deprivation therapy while also generally being associated with a mild toxicity profile and has thus garnered interest as a means to delay systemic therapy. Here we review the evidence surrounding the use of radiation therapy to metastatic sites in patients with metastatic hormone-sensitive prostate cancer.

MeSH terms

  • Ablation Techniques / methods
  • Ablation Techniques / standards
  • Clinical Trials as Topic
  • Evidence-Based Medicine / methods
  • Evidence-Based Medicine / standards
  • Humans
  • Male
  • Neoplasm Recurrence, Local / epidemiology
  • Neoplasm Recurrence, Local / pathology
  • Neoplasm Recurrence, Local / radiotherapy*
  • Progression-Free Survival
  • Prostate / pathology
  • Prostate / radiation effects
  • Prostatic Neoplasms / mortality
  • Prostatic Neoplasms / pathology
  • Prostatic Neoplasms / radiotherapy*
  • Radiation Oncology / methods
  • Radiation Oncology / standards*
  • Radiosurgery / methods
  • Radiosurgery / standards*
  • Standard of Care*