Coordinated inhibition of nuclear export and Bcr-Abl1 selectively targets chronic myeloid leukemia stem cells

Leukemia. 2020 Jun;34(6):1679-1683. doi: 10.1038/s41375-020-0708-1. Epub 2020 Jan 24.
No abstract available

Publication types

  • Letter
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Active Transport, Cell Nucleus / drug effects*
  • Animals
  • Antineoplastic Agents / pharmacology*
  • Drug Resistance, Neoplasm / drug effects
  • Fusion Proteins, bcr-abl
  • Hematopoietic Stem Cells / drug effects
  • Humans
  • Hydrazines / pharmacology*
  • Imatinib Mesylate / pharmacology
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive / metabolism*
  • Mice
  • Neoplastic Stem Cells / drug effects*
  • Triazoles / pharmacology*
  • Tumor Cells, Cultured
  • Xenograft Model Antitumor Assays

Substances

  • Antineoplastic Agents
  • BCR-ABL1 fusion protein, human
  • Hydrazines
  • Triazoles
  • selinexor
  • Imatinib Mesylate
  • Fusion Proteins, bcr-abl