Anticoagulation Strategies in the Perioperative Period for Lung Transplant

Yaron D Barac; Jacob Klapper; Angela Pollack; Jessica Poisson; Ian Welsby; M G Hartwig; Brandi Bottiger

doi:10.1016/j.athoracsur.2019.11.056

Anticoagulation Strategies in the Perioperative Period for Lung Transplant

Ann Thorac Surg. 2020 Jul;110(1):e23-e25. doi: 10.1016/j.athoracsur.2019.11.056. Epub 2020 Jan 22.

Authors

Yaron D Barac¹, Jacob Klapper², Angela Pollack³, Jessica Poisson⁴, Ian Welsby³, M G Hartwig², Brandi Bottiger³

Affiliations

¹ Division of Cardiovascular and Thoracic Surgery, Duke University Medical Center, Durham, North Carolina. Electronic address: [email protected].
² Division of Cardiovascular and Thoracic Surgery, Duke University Medical Center, Durham, North Carolina.
³ Division of Cardiothoracic Anesthesiology, Duke University Medical Center, Durham, North Carolina.
⁴ Department of Pathology, Duke University Medical Center, Durham, North Carolina.

PMID: 31981503
DOI: 10.1016/j.athoracsur.2019.11.056

Abstract

Patients who are undergoing lung transplantation may require systemic anticoagulation in the perioperative period for various indications at the time of the procedure. Four-factor prothrombin complex concentrate has been approved in the United States to reverse the effects of warfarin for patients requiring urgent surgery. We describe a perioperative anticoagulation strategy with warfarin that is reversed before incision using 4-factor complex concentrate for off-pump lung transplant recipients.

Publication types

Case Reports

MeSH terms

Adult
Anticoagulants / therapeutic use
Blood Coagulation / drug effects
Blood Coagulation Factors / therapeutic use*
Humans
Lung Transplantation*
Perioperative Care / methods*
Thrombosis / prevention & control*
Transplant Recipients*
Warfarin / therapeutic use*

Substances

Anticoagulants
Blood Coagulation Factors
prothrombin complex concentrates
Warfarin