Escherichia coli O-antigen capsule (group 4) is essential for serum resistance

Dvora Biran; Ilan Rosenshine; Eliora Z Ron

doi:10.1016/j.resmic.2019.12.002

Escherichia coli O-antigen capsule (group 4) is essential for serum resistance

Res Microbiol. 2020 Mar;171(2):99-101. doi: 10.1016/j.resmic.2019.12.002. Epub 2020 Jan 24.

Authors

Dvora Biran¹, Ilan Rosenshine², Eliora Z Ron³

Affiliations

¹ School of Molecular Cell Biology and Biotechnology, Life Sciences, Tel Aviv University, Tel Aviv, 69978, Israel.
² Department of Molecular Genetics and Biotechnology, The Hebrew University, Faculty of Medicine, POB 12272, Jerusalem, 91120, Israel.
³ School of Molecular Cell Biology and Biotechnology, Life Sciences, Tel Aviv University, Tel Aviv, 69978, Israel. Electronic address: [email protected].

PMID: 31982499
DOI: 10.1016/j.resmic.2019.12.002

Abstract

Many septicemic Escherichia coli strains produce polysaccharide capsules, which are important for survival in serum. Here we show that a septicemic E. coli strain of serotype O78 produce an O-antigen capsule (group 4 capsule) and we show that this capsule is essential for serum survival.

Keywords: Capsule; Colisepticemia; Extraintestinal pathogenic E. coli (EXPEC); Group 4 capsule; Sepsis; Serum survival.

MeSH terms

Bacterial Capsules / immunology*
Escherichia coli / immunology*
Escherichia coli Infections / immunology*
Escherichia coli Infections / microbiology*
O Antigens / immunology*
Operon
Virulence

Substances

O Antigens