Abstract
In the present study, we examined the effects of interleukin (IL)-10 expression-inducing bacteria Bifidobacterium adolescentis HP1, Lactobacillus mucosae HP2, and Weissella cibaria HP3 on high-fat diet (HFD)-induced obesity and liver steatosis in mice. Oral gavage of HP1, HP2, and HP3 reduced HFD-induced bodyweight gain, triglycerides, and total cholesterol levels in the blood and liver. They also suppressed HFD-induced colitis and the fecal δ,γ-Proteobacteria population. Of the tested bacteria, HP2, which most potently inhibited IL-10 expression, also suppressed HFD-induced bodyweight gain, liver steatosis, and colitis most effectively. These findings suggest that IL-10 expression-inducing gut bacteria can suppress obesity and liver steatosis.
Keywords:
Gut bacteria; IL-10; colitis; liver steatosis; obesity.
MeSH terms
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Animals
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Bifidobacterium adolescentis / physiology
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Colitis / drug therapy
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Colitis / etiology
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Colitis / metabolism
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Diet, High-Fat / adverse effects*
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Fatty Liver / drug therapy
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Fatty Liver / etiology
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Fatty Liver / metabolism
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Gastrointestinal Microbiome / drug effects
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Gastrointestinal Microbiome / physiology*
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Hyperlipidemias / drug therapy*
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Hyperlipidemias / etiology
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Hyperlipidemias / metabolism
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Interleukin-10 / metabolism*
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Lactobacillus / physiology
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Liver / drug effects
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Liver / metabolism
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Macrophages / drug effects
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Macrophages / metabolism
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Male
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Mice
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Mice, Inbred C57BL
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Obesity / drug therapy*
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Obesity / etiology
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Obesity / metabolism
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Probiotics / administration & dosage
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Probiotics / pharmacology
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Weight Gain / drug effects
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Weissella / physiology
Substances
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IL10 protein, mouse
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Interleukin-10
Supplementary concepts
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Lactobacillus mucosae
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Weissella cibaria