Hippo pathway effectors YAP/TAZ as novel determinants of ferroptosis

Wen-Hsuan Yang; Jen-Tsan Chi

doi:10.1080/23723556.2019.1699375

Hippo pathway effectors YAP/TAZ as novel determinants of ferroptosis

Mol Cell Oncol. 2019 Dec 10;7(1):1699375. doi: 10.1080/23723556.2019.1699375. eCollection 2020.

Authors

Wen-Hsuan Yang^{1

2

3}, Jen-Tsan Chi^{1

2}

Affiliations

¹ Department of Molecular Genetics and Microbiology.
² Center for Genomic and Computational Biology.
³ Department of Biochemistry, Duke University School of Medicine, Durham, NC, USA.

Abstract

Ferroptosis is a novel form of programmed cell death. We found that the ferroptosis sensitivity in renal and ovarian cancers are regulated by cell density through TAZ-EMP1-NOX4 and TAZ-ANGPTL4-NOX2 pathway, respectively. These findings reveal TAZ as a novel genetic determinant of ferroptosis. Triggering ferroptosis may have therapeutic potential for TAZ-activated tumors.

Keywords: Angiopoietin-Like 4 (ANGPTL4); Epithelial Membrane Protein 1 (EMP1); Erastin; Ferroptosis; Hippo pathway; NADPH Oxidase 2 (NOX2); NADPH Oxidase 4 (NOX4); Ovarian Cancer; Renal Cell Carcinoma; Yes-associated protein 1 (YAP1); transcriptional coactivator with PDZ-binding motif (TAZ).

Abstract

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